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ea0094p352 | Metabolism, Obesity and Diabetes | SFEBES2023

Metabolic phenotyping of the polygenic mouse model (NONcNZO10/LtJ) of type 2 diabetes to mimic the process of diabetes development and remission in human

Ojeda Laura , Onishi Ami , Junior Jair , Von Kriegsheim Alex , Morton Nicholas , Al-Mrabeh Ahmad

Background and Aims: Obesity is a major risk factor for type 2 diabetes (T2D). Remission of diabetes can be achieved by dietary weight loss although the underlying molecular mechanism(s) are unknown. These beneficial effects could be related to decreasing hepatic fat delivery to the pancreas and eventually restoring β-cell function. We hypothesised that hepatic de novo lipogenesis (DNL) is the primary driver of pancreas lipotoxicity and the pr...

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ea0086oc5.1 | Metabolism, Obesity and Diabetes | SFEBES2022

Human brown adipose tissue demonstrates substantial choline uptake for incorporation into phosphatidylcholines

Suchacki Karla , Ramage Lynne , Gray Calum , Rodrguez Blanco Giovanny , Choong Kwok T'ng , Boyle Luke , MacNaught Gillian , Gregoriades Maria-lena , Wakelin Sonia , von Kriegsheim Alex , Finch Andrew , Patel Dilip , van Beek Edwin , Stimson Roland

Background: 18F-fluorodeoxyglucose (18FDG) PET is commonly used to quantify brown adipose tissue (BAT) mass/activity in humans but requires cold exposure. Rodent brown (BAds) but not white adipocytes (WAds) exhibit high choline content, thus we hypothesised that human BAT would demonstrate substantial 18F-fluorocholine (18FCH) uptake in vivo during warm and cold conditions.Methods: (1)...

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Endocrine Abstracts

Metabolic phenotyping of the polygenic mouse model (NONcNZO10/LtJ) of type 2 diabetes to mimic the process of diabetes development and remission in human

Human brown adipose tissue demonstrates substantial choline uptake for incorporation into phosphatidylcholines

BiosciAbstracts